Muscle satellite cell heterogeneity and self-renewal
نویسندگان
چکیده
منابع مشابه
Muscle satellite cell heterogeneity and self-renewal
Adult skeletal muscle possesses extraordinary regeneration capacities. After muscle injury or exercise, large numbers of newly formed muscle fibers are generated within a week as a result of expansion and differentiation of a self-renewing pool of muscle stem cells termed muscle satellite cells. Normally, satellite cells are mitotically quiescent and reside beneath the basal lamina of muscle fi...
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Adult muscle stem cells, or satellite cells have essential roles in homeostasis and regeneration of skeletal muscles. Satellite cells are located within a niche that includes myofibers and extracellular matrix. The function of specific extracellular matrix molecules in regulating SCs is poorly understood. Here, we show that the extracellular matrix protein collagen VI is a key component of the ...
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Skeletal muscle possesses a remarkable ability for regeneration and can go through rapid repair following muscle injury. This regeneration depends on the activity and contributions of muscle satellite cells, which are located between the sarcolemma of myofibers and the basal lamina [1]. Upon muscle injury, satellite cells are activated, driven out of their quiescent state, and start to prolifer...
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Satellite cells are situated beneath the basal lamina that surrounds each myofiber and function as myogenic precursors for muscle growth and repair. The source of satellite cell renewal is controversial and has been suggested to be a separate circulating or interstitial stem cell population. Here, we transplant single intact myofibers into radiation-ablated muscles and demonstrate that satellit...
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Satellite cells are the resident stem cells of adult skeletal muscle. As with all stem cells, how the choice between self-renewal or differentiation is controlled is central to understanding their function. Here, we have explored the role of beta-catenin in determining the fate of myogenic satellite cells. Satellite cells express beta-catenin, and expression is maintained as they activate and u...
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ژورنال
عنوان ژورنال: Frontiers in Cell and Developmental Biology
سال: 2014
ISSN: 2296-634X
DOI: 10.3389/fcell.2014.00001